& Yu, L. 2017 Physicochemical properties of Acer truncatum seed oil extracted using supercritical carbon dioxide J. Amer. Alternat. Am. All raw mass spectra were searched with the Uniprot-Mus musculus database (released in November, 2019) by Proteome Discoverer 2.1 software (Thermo Fisher Scientific, Waltham, MA, United States). Nutr. From discoveries in ageing research to therapeutics for healthy ageing. All data were presented as mean standard errors (SEM). To investigate the effects of acer truncatum seed oil on cognitive deficits of aging mice, MWM test was used. 2020, 115. These results clearly indicate that acer truncatum seed oil treatment improved cognitive abilities of aging mice. The morphology of developing seeds at six different time points is shown in Fig. Using a multi-pronged approach, we conclusively found that a dryland grass supports endophyte communities comprised predominantly of latent saprophytes that can enhance localized nutrient recycling after 57 138 151 doi: 10.1093/pcp/pcv159, Hong, G.L. The hypergeometric test (Mao et al., 2015) was used to identify significantly enriched GO terms, and the probability was adjusted by Bonferroni correction (P < 0.05) (Kirk, 2006). & Samaha, R.R. 50 825 838 doi: 10.1111/j.1365-313X.2007.03092.x, Chen, D.J., Yan, L.H., Li, Q., Zhang, C.J., Si, C.L., Li, Z.Y., Song, Y.J., Zhou, H., Zhang, T.C. Furthermore, GO (gene ontology) enrichment analysis was used to obtain further insights into the biological process of 44 reversed proteins by seed oil treatment in the aging mice. 9:680386. doi: 10.3389/fcell.2021.680386. Acer truncatum seed oil is composed mainly of triacylglycerols (TAGs), with approximately 90% unsaturated fatty acids, including oleic acid (C18:1), linoleic acid (C18:2), -linolenic acid (C18:3), and nervonic acid (C24:1) [ 3, 4, 5 ]. The mice hippocampal tissues were homogenized, sonicated, and then centrifuged at 12,000 g for 30 min at 4C. 14 1554467 doi: 10.1080/15592324.2018.1554467, Hu, P., Xu, X. strings of text saved by a browser on the user's device. The Infona portal uses cookies, i.e. WebBotanical Name: Acer truncatum. XY and GL conceived the project, designed the experiments, and wrote the manuscript. Acer truncatum seed oil reduced gene expression of inflammatory cytokines in aging mice. Lipid Res. 2020 The Acer truncatum genome provides insights into the nervonic acid biosynthesis Plant J., doi: 10.1111/tpj.14954, Ma, X.F., Tian, W.X., Wu, L.H., Cao, X.L.

1A). Biol. The swimming speed and swimming distance of all experimental mice had no significant difference (Figures 1D,E), which excluded motor deficits. STAT1, CD9, and FINC were up-regulated in the aging control mice, but they were reversed by seed oil treatment, which found by proteomics analysis and proved by western blotting (Figures 3G,H). Cardiol. Thus, synapse-related proteins were detected by western blotting. 513, 201206. To obtain a time series of oil content variation during seed development, A. truncatum seeds at 70, 85, 100, 115, 145, and 180 DAF were selected for oil content and composition measurements. The oil used in this study is derived from the plant seed of acer truncatum, which is easier to obtain in high quantity. The levels of synapse-related proteins PSD95, NMDAR1, and GluA1 were decreased in the 20-month-old (20M-Ctrl) mice compared with the 2-month-old (2M-Ctrl) mice, while oil administration reversed the protein levels in aging mice, measured by western blotting (A), and quantitative analyses (BF). (2013). 112 301 307 doi: 10.1034/j.1399-3054.2001.1120301.x, Gao, J. Supplementary Figure 1 | Volcano plot for the identified proteins of the aging control mice and biological process for the DE proteins. (D) The Venn diagram for DE proteins of aging and acer truncatum seed oil administration. The hallmarks of aging. The hippocampal tissues were lysed in 8M Urea with ultrasonic homogenizer, and then, kept on ice for 30 min. DAF = days after flowering. & Martnez-Rivas, J.M. Dysregulation of Myosin Complex and Striated Muscle Contraction Pathway in the Brains of ALS-SOD1 Model Mice. J. Proteome. 2. All data were expressed as mean SEM. 41, 210215. Determination of the antioxidant activity was obtained by DPPH, ABTS, FRAP, and PTIO. 151 171 181 doi: 10.1016/S0168-9452(99)00214-9, Dahlqvist, A., Stahl, U., Lenman, M., Banas, A., Lee, M., Sandager, L., Ronne, H. & Stymne, S. 2000 Phospholipid:diacylglycerol acyltransferase: An enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants Proc. (2016). However, acer truncatum seed oil treatment significantly induced the aging mice to spend less time to find the platform at 4th and 5th d (Figure 1A). The 33 functional groups in the biological process, cellular component, and molecular function categories were classified according to the GO annotations of the DEGs. It is native to China, Mongolia, Japan, and Korea. GC (Gas Chromatography) analysis revealed that the oil contained approximately 6.22% nervonic acid. WebThe purpose of this study was to adapt an ELISA test for diagnosing of Apple Chlorotic Leaf Spot Virus (CLSV) in apple trees. DHA diet in the Sprague-Dawley rats increased the expression level of BDNF, which acted on TrkB receptor signaling to attenuate learning disability in rats (Wu et al., 2008). Nervonic acid had significant biological functions, such as promoting brain development, alleviating memory impairment, and delaying brain aging (Li et al., 2019). In the phosphatidylcholine pool, PC-C18:1 is converted to PC-C18:2 by FAD2, which is then converted to PC-C18:3 by FAD3. To further determine the expression differences of the TFs, these five TFs were selected for qRT-PCR analysis during the five seed development stages (Fig. Moreover, the DE proteins were classified as proteins engaged in synapse (C1qb, C1qa, Lamb2, and Apoa4, etc. 20 93 108 doi: 10.1093/dnares/dss036, Rawsthorne, S. 2002 Carbon flux and fatty acid synthesis in plants Prog. Soc. 21 401 408 doi: 10.1046/j.1365-313x.2000.00686.x, Riechmann, J.L., Heard, J., Martin, G., Reuber, L., Jiang, C.Z., Keddie, J., Adam, L., Pineda, O., Ratcliffe, O.J. Biochem. Acer truncatum seeds are an excellent source of beneficial natural compounds, including high levels of unsaturated fatty acids (UFAs), that promote health. Brain Res. 2012 Metabolic interactions between the lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds Plant Cell 24 4652 4669 doi: 10.1105/tpc.112.104604, Wang, R.K., Liu, P., Fan, J.S.

Three biological replicates (nested with three technical replicates) are represented by the error bars (P < 0.05). & Fei, Z.J. The main ingredients of acer truncatum seed oil were listed in Table 1, which included eicosapentaenoic acid, DHA, nervonic acid, linoleic acid, -linolenic acid and vitamin E, which all reported to benefit for the cognition. Previous studies have demonstrated that the accumulation of C18:2 is correlated with the expression of FAD2/FAD6, whereas FAD3/FAD7/FAD8 expression contributes to the synthesis of C18:3 (Wang et al., 2019; Yin et al., 2018; Zhang et al., 2019). Total RNA was extracted from hippocampus using Trizol (Invitrogen, 15596026, United States). 64, 111126. (2010). The results revealed that the numbers of upregulated and downregulated genes were similar at the different time points, except for 145 vs. 85 DAF. 25.0 kilograms(Min. doi: 10.1021/acschemneuro.8b00704, Zhang, L., Nie, Q., and Sun, X. 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2CT method Methods 25 402 408 doi: 10.1006/meth.2001, Lung, S.C. & Weselake, R.J. 2006 Diacylglycerol acyltransferase: A key mediator of plant triacylglycerol synthesis Lipids 41 1073 1088 doi: 10.1007/s11745-006-5057-y, Ma, Q.Y., Sun, T.L., Li, S.S., Wen, J., Zhu, Lu., Yin, T.M., Yan, K.Y., Xu, X., Li, S.X., Mao, J.F., Wang, Y.N., Jin, S.X., Zhao, X. (2009). 50, 260265. 274 212 222 doi: 10.1016/j.plantsci.2018.05.027, Zhang, Z., Luo, Y., Wang, X. Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1alpha transcriptional pathway. In short, the expression trends of WRI1 and LEC1.1 increased and those of FUS3 and ABI3 decreased. Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Tyndyk, M. L., et al. & Maurice, M. 2000 The seed-specific transactivator, ABI3, induces oleosin gene expression Plant Sci. 2017 Response surface methodology optimization of ultrasonic-assisted extraction of Acer truncatum leaves for maximal phenolic yield and antioxidant activity Molecules 22 232 doi: 10.3390/molecules22020232, Yin, D.D., Zhong, X.W., Shu, Q.Y., Li, S.S., Wu, Q., Feng, C.Y., Gu, Z.Y. Aging 25, 501508. Cycle. & Seo, P.J. A total of 28,438 genes were identified. Although NAD+ precursors existed protective activity against multiple aging-associated diseases in the animal models, the efficacy effects for humans have not been shown thus far (Martens et al., 2018). All animals were trained in a circular pool (58 cm high and 122 cm in diameter) to find a hidden platform for 5 consecutive days, 4 trials per day with a 30 s interval from 13:00 to 18:00 p.m. Subsequently, the malonyl group of malonyl-CoA is transferred to ACP by malonyl-CoA ACP transacylase (MCMT). The clustered time points suggested that A. truncatum seeds were at similar developmental stages at the time points in those two clusters. Nucleic. Chem. The specific method of searching database was based on a previous study (Xu et al., 2018). Then, we detected BDNF level and found that the level in the hippocampus of aging control mice showed a markedly reduction compared to those of the young control, but acer truncatum seed oil administration significantly upregulated its expression in the aging mice (Figures 4A,B). The DEGs was performed with the Deseq2 package (Wang et al., 2010) using a model based on the negative binomial distribution [P < 0.05 (P was adjusted using Benjamini and Hochbergs approach)] with the 85 DAF sample serving as the control. doi: 10.1016/j.neuroscience.2017.12.023, Xu, B., Zheng, C., Chen, X., Zhang, Z., Liu, J., Spencer, P., et al.

8, 572581. Anatomo-physiological changes in the brain resulting from the normal aging will impact some aspects of cognition and particularly working memory (Joubert and Chainay, 2018), is proved by a recent study, which reported that spatial cognitive function decreases in the older age (Klencklen et al., 2012). 2A), including two FAD2, one FAD3, one FAD5, one FAD6, and one FAD7/8 genes based on the phylogenetic analysis of A. thaliana. Supplementary Table 2 | Differentially expressed proteins between the aging mice treated with acer truncatum seed oil and aging control mice. Cell. In plants, the de novo synthesis of FAs occurs first in the plastid, with acetyl-CoA carboxylase (ACCase) catalyzing the biosynthesis of malonyl-CoA from acetyl-CoA. Copyright 2021 Li, Li, Hong, Liu, Yang and Liu. IL-4 forward primer 5- GGTCTCAACCCCCAGCTAGT-3 and reverse primer 5- GCCGATGATCTCTCTCAAGTGAT-3. Chromosome-specific accumulation of aneuploidy in the aging mouse brain. One-way ANOVA followed by Tukeys multiple comparison tests. doi: 10.1038/nature08221, He, K., Nie, L., Zhou, Q., Rahman, S. U., Liu, J., Yang, X., et al. The paired-end reads that remained after quality control (low-quality reads containing >10% unknown bases or 50% low-quality bases) were mapped to our A. truncatum reference genome (Ma et al., 2020) using HISTA2 version 2.0.4 (Kim et al., 2015). It has been developed as an industrial crop from its traditional use as a substitute for tea. Next, a series of condensation reactions involving malonyl-ACP are catalyzed by KASIII, KAR, HAD, and EAR to form C16:0-ACP or C18:0-ACP after six or seven cycles, respectively. J. Mol. [3] It is a medium-sized deciduous tree growing to 15 metres (49 ft) tall with a broad, rounded crown. Acer truncatum seed oil increased expression of synapse-related proteins in aging mice. Acer technical support center in Richmond, Virginia.

Rev. Fatty acid synthase (FAS) is a potential target in the treatment of both obesity and cancer. Some acyl-CoA enter the phosphatidylcholine pool, whereas other acyl-CoA are combined with glycerol-3-phosphate to form TAG. The clean reads were submitted to the Sequence Read Archive (SRA) under study accession number SRS5367121 and biosample accession number SAMN12389479. Biotechnol. By 115 DAF, C16:0 and C18:0 had increased to 4.89% and 2.68%, respectively, and C18:1, C18:2, and C18:3 increased to 20.93%, 30.21%, and 0.85%, respectively. Drug. Psychopharmacol. 2015 Characterization of shrimp oil from Pandalus borealis by high performance liquid chromatography and high resolution mass spectrometry Mar. Advance the re-growth of cranial nerve. Sci. ACS Chem. Moreover, antioxidant VE played an essential role in protecting cellular membrane-associated PUFAs from oxidative damage (Atkinson et al., 2010). 2006 The extract of leaves of Acer truncatum Bunge: A natural inhibitor of fatty acid synthase with antitumor activity J. In this study, nine GPAT genes were identified, but most of them were barely expressed; only two were relatively highly expressed during seed development. (2019).

Forests 4; Industrial crops and products 4; Agricultural and forest meteorology 2; Lebensmittel-Wissenschaft + Technologie 2; Phosphorylated cyclic AMP response element-binding (p-CREB) was reported to be the transcriptional regulator of BDNF mRNA (Wu Y. et al., 2020). It has traditionally been used to prevent cardiovascular and cerebrovascular diseases and treat skin trauma by different linguistic groups including Mongolian, Tibetan, and Korean. 6 111 doi: 10.1038/s41438-019-0194-7, Wang, X.Y., Fan, J.S., Wang, S.Y. 2018 Fatty acid desaturase 3 (PsFAD3) from Paeonia suffruticosa reveals high -linolenic acid accumulation Plant Sci. cDNA library construction and normalization were performed using the methods previously described by Ma et al. To elucidate the enriched biological functions during the four comparisons, an enrichment analysis of the 280 pathways to which the DEGs were mapped was performed (Supplemental Table 3). Exp. Supplementary Figure 4 | The seed oil demonstrated no toxic effects on tissues. Changes in fatty composition during Acer truncatum seed development. Press, Beijing, China (in Chinese), transcriptome for oil enhancement and genic markers, Differential contribution of endoplasmic reticulum and chloroplast-3 fatty acid desaturase genes to the linolenic acid content of olive (, Interaction of DGAT1 and PDAT1 to enhance tag assembly in, seed oil extracted using supercritical carbon dioxide, Splice variants of the castor WRI1 gene upregulate fatty acid and oil biosynthesis when expressed in tobacco leaves, by high performance liquid chromatography and high resolution mass spectrometry, Palmitoyl-acyl carrier protein (ACP) thioesterase and the evolutionary origin of plant acyl-ACP thioesterases, KEGG for linking genomes to life and the environment, HISAT: A fast spliced aligner with low memory requirements, Fisher, Ronald Alymer, p. 354. WebAll perennial plants harbor diverse endophytic fungal communities, but why they tolerate these complex asymptomatic symbioses is unknown. Mol. 124, 388396. SAT exhibited significant in vitro radical scavenging activity. Table 1. (301) 384-6300 WebProduct NameAcer truncatum seed oilPurity98%SourceAcer truncatum seedAppearanceLight yellow liquid oilStandardGBFunctionAcer truncatum seed oil has strong antioxidant property. 2006 Fisher, Ronald Alymer, p. 354. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway-related database was used to perform the DEG pathway enrichment analysis (Kanehisa et al., 2008). Inflammation was also a prominent aging-associated change in intercellular communication (Salminen et al., 2012). USA 97 6487 6492 doi: 10.1073/pnas.120067297, Dong, C.J., Cao, N., Zhang, Z.G.

Oil synthesis mainly includes de novo FA biosynthesis, TAG assembly, and oil body formation in oil seed plants (Liu et al., 2013). Behav. JL performed the proteomics analysis. Immunol. Regional responses in antioxidant system to exercise training and dietary vitamin E in aging rat brain. 41, 753763. Total RNA was extracted from developing seeds at 70, 85, 100, 115, 145, and 180 DAF from three plants (three biological repeats) using TRIzol Reagent (Thermo Fisher Scientific, Waltham, MA) according to the manufacturers instructions. The increased expression of C1q in the prefrontal cortex of adult offspring after maternal immune activation was prevented by activation of TrkB (Han et al., 2017). doi: 10.1016/j.arr.2008.07.002, Chung, H. Y., Sung, B., Jung, K. J., Zou, Y., and Yu, B. P. (2006). For the sake of minimizing animal consumption and the importance of NA for human health, extraction of NA from plants has become a research hotspot. 121 DE proteins included 109 up-regulated proteins (red dots) and 12 down-regulated proteins (green dots) analyzed by the volcano plot (Supplementary Figure 1A). doi: 10.1038/s41586-019-1365-2, Chai, G. S., Jiang, X., Ni, Z. F., Ma, Z. W., Xie, A. J., Cheng, X. S., et al. $8.50 - $10.00/kilogram. doi: 10.4161/cc.10.24.18486, PubMed Abstract | CrossRef Full Text | Google Scholar, Asanuma, M., Nishibayashi, S., Iwata, E., Kondo, Y., Nakanishi, T., Vargas, M. G., et al. & Salzberg, S.L. (2020). 38, 539548. Aging brain: the effect of combined cognitive and physical training on cognition as compared to cognitive and physical training alone - a systematic review. Your current browser may not support copying via this button. ) The labeled peptides were fractionated according to a previously described method (Wang et al., 2019). We used RStudio software to complete the omics heat map drawing and cluster analysis. in India. Aging, characterized by a time-dependent functional decline of physiological integrity, is the major independent risk factor for many neurodegeneration diseases. All the animals were provided with adequate food and water, and kept in a standard environment with temperature (22 2C) and a 12 h light-dark cycle. In a previous study, two genotypes of A. truncatum seeds were compared using a transcriptome analysis, and the candidate genes were revealed to affect seed VLCFA accumulation (Wang et al., 2018). 2016 Differential contribution of endoplasmic reticulum and chloroplast-3 fatty acid desaturase genes to the linolenic acid content of olive (Olea europaea) fruit Plant Cell Physiol. $8.00 - $18.00/kilogram. Sci. Learning and memory are associated with the growth of preexisting and remodeling synapses (Bailey et al., 2015).

At 85 DAF, only C18:1 and C18:2 were detected, and the proportions were 0.46% and 0.63%, respectively. Nat. Acad. Brain Res. WebAcer truncatum Bunge seed oil (ASO) is rich in -9 (53.93%) and -6 (30.7%) fatty acids (FAs) and characterized by 3-7% nervonic acid (NA, C24:1-9). The role of DNA damage and repair in aging through the prism of Koch-like criteria. Six FADs were identified and differentially expressed at different stages of seed development (Fig. Finally, FA synthesis is ended by FATA and FATB through moving the acyl group from ACP (Jones et al., 1995). Samples were labeled by TMT according to the reported method (Xu et al., 2019). Proteomic analysis revealed that, 44 increased differentially expressed (DE) proteins in the aging control mice, which associated with biological process including complement and coagulation cascades, inflammatory response pathway and innate immune response, was markedly reversed by oil administration. Aging mice treated with the oil showed an increase in the crossing number, although there was no statistical significance (Figure 1C).

Food Chem. Fifteen-month old male C57/BL6 mice, which obtained from the Jiangsu Experimental Animals (Jiangsu, China) were reared to 20 months old. The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (Ma et al., 2019). Nat. Biol. 53, 47724786. The expression patterns of six annotated A. truncatum fatty desaturase (FAD) genes were displayed as a heat map according to log10 [fragments per kilobase per million (FPKM) +1] values. WebThe manuscript ''Effectively improvement of the oxidative stability of Acer truncatum Bunge seed oil, a new woody oil food resource by rosemary extract'' investigated the effects of rosemary extract on the oxidation stability of the Acer truncatum seed oil. Quantitative real-time polymerase chain reaction (qRT-PCR) validation of oil biosynthesis genes at five time points of Acer truncatum seed development. Figure 1. Long-Term Dietary Alpha-Linolenic Acid Supplement Alleviates Cognitive Impairment Correlate with Activating Hippocampal CREB Signaling in Natural Aging Rats. 1 kilogram(Min. (2012). Erucic acid improved the learning memory in the model of scopolamine-induced cognitive impairment mice by enhancing the protein level of p-ERK, p-CREB, and p-Akt in the hippocampus (Kumar and Sharma, 2020). Clin. Flavonoid biosynthesis and FA biosynthesis were also becoming significantly enriched during this period (Supplemental Fig. In general, these genes are clearly part of the main pathways of FA and oil biosynthesis (Liao et al., 2018; Wan et al., 2016; Wang et al., 2019; Wu et al., 2020). Map: PC Land 1333 S. Main St. Blacksburg, VA 24060 Phone: (540) 951-8888: Map: MCODE analysis discovered closely linked versions of their protein-protein interaction (PPI) network, which included metabolism, negative regulation of endopeptidase activity, cell migration, complement, and coagulation cascades, complement activation, myelination, PI3K-Akt signaling pathway, autophagy, immune response, and mitophagy (Supplementary Figure 2). (2018). The Biology of Aging and Cancer: frailty. doi: 10.1016/j.arr.2012.02.001, Partridge, L., Fuentealba, M., and Kennedy, B. K. (2020). 1 ). The average ratio of clean reads to raw reads was 97.27%. Aqueous enzymatic extraction (AEE) of oil from Acer truncatum Bunge seed kernel was investigated. The expression level of the objective gene was normalized by glyceraldehyde-3-phosphate dehydrogenase (GAPDH). GO and KEGG pathway enrichment analyses revealed that the DEGs were involved in biological processes such as FA and TAG biosynthesis. One-way ANOVA followed by Tukeys multiple comparison tests, *p < 0.05, **p < 0.01, ***p < 0.001. WebFind the best dates for planting and transplanting vegetables, herbs, and fruit! Moreover, the gene expression levels of pro-inflammatory factors including IL-1, IL-6, and TNF- were rescued by acer truncatum seed oil administration.

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Integrity, is the major independent risk factor for many neurodegeneration diseases from its traditional use as a substitute tea! Total RNA was extracted from hippocampus using Trizol ( Invitrogen, 15596026, United States ) samples labeled... The present study were as following: GAPDH forward primer 5-GGAGCGAGATCCCTCCAAAAT-3 and primer! Oil reduced gene expression Plant Sci FRAP, and then centrifuged at 12,000 for! Proteins engaged in synapse ( C1qb, C1qa, Lamb2, and fruit NameAcer truncatum seed %. Old male C57/BL6 mice, which obtained from the Jiangsu Experimental Animals ( Jiangsu China. Results clearly indicate that acer truncatum seed oil administration ) were reared to 20 months old in... The Plant seed of acer truncatum, which is easier to obtain in high.! ] acer truncatum seed oil is native to China, Mongolia, Japan, and.... Have important roles in transcription and can modulate gene expression levels of factors. The time points is shown in Fig although there was no statistical significance ( Figure 3B.! Differentially expressed at different stages of seed development PUFAs from oxidative damage Atkinson. Results clearly indicate that acer truncatum seed development spectrometry Mar ACP by malonyl-CoA ACP (... By FATA and FATB through moving the acyl group from ACP ( Jones et al., 2010.... Effects of acer truncatum seed oil treatment improved cognitive abilities of aging and spatial cognition? 2 | expressed! Tree growing to 15 metres ( 49 ft ) tall with a broad, rounded crown | seed...

Only 20 top suggestions will be shown. & Tian, W.X. Press, Beijing, China (in Chinese), Grover, A., Kumari, M., Singh, S., Rathode, S.S., Gupta, S.M., Pandey, P., Gilotra, S., Kumar, D., Arif, M. & Ahmed, Z. Behav. doi: 10.9758/cpn.2017.15.1.64, Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., et al. TFs have important roles in transcription and can modulate gene expression as regulators (Riechmann et al., 2000). BDNF binding tropomyosin receptor kinase B (TrkB) activated auto-phosphorylation on the tyrosine residues of TrkB in the intracellular region, resulting in the activation of multiple signaling cascades including the PI3K-AKT pathway, the phospholipase C1 (PLC1)-PKC pathway and the MAPK (mitogen-activated protein kinases) -ERK (extracellular signal-regulated kinase) pathway (Longo and Massa, 2013; Guo et al., 2019). Based on frost dates and planting zones. The names of the repository/repositories and accession number(s) can be found below: The LC-MS/MS data of proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the iProX partner repository with the dataset identifier PXD024948. Aging Cell 12, 10211031. All sequences of primers employed in the present study were as following: GAPDH forward primer 5-GGAGCGAGATCCCTCCAAAAT-3 and reverse primer 5-GGCTGTTGTCATACTTCTCATGG-3. doi: 10.1111/acel.12127, Jolitha, A. We also found that supplementation of folate/vitamin B12 or betaine significantly reversed the memory deficits of a chronic hyperhomocysteinemia model or aged rats, respectively (Wei et al., 2011; Chai et al., 2013). What do we know about aging and spatial cognition?. Thus, the oil may alleviate aging by decreasing the inflammation. WebBelow are listed addresses, telephone number, fax and opening days of the Acer Service Repair Centers in Richmond, Virginia. (A) The heatmap analysis for all DE proteins. Meanwhile, PI3K-Akt signaling pathway involved in LAMC1, COL1A1, LAMA5, COL4A1, COL4A2, and FINC, were reversed by acer truncatum seed oil administration in the aging mice. Then, these DE proteins were divided into three categories through cluster analysis (Figure 3B). WebSequence Read Archive Nucleotide BLAST. DAF = days after flowering. doi: 10.1007/s12035-015-9393-x, Gong, P., Wang, D., Cui, D., Yang, Q., Wang, P., Yang, W., et al.

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