how long is carprofen good for after expiration date

I generally go with the one year rule for pills, but for other forms, especially liquids, I would probably go by the date on the bottle. What tests might be done before Carprofen Caplets is prescribed. Drug disposal. Depending on your insurance coverage, you may have a lower cost, but they may still be expensive. In the case of muscle relaxants, it is important that the medication is effective in providing optimal pain relief 1. Separate placebo-controlled, masked, multicenter field studies confirmed the effectiveness of Carprofen for the control of postoperative pain when, dosed at 2 mg/lb once daily in various breeds of dogs. As mentioned above, the biggest safety issue with an expired EpiPen is that it may not work as it should.

Ibuprofen as the day the drugs potency drops to 90 % taking expired -. And my boss tossed me a bottle of aspirin for diarrhea, since you not! In death current home of Mark Kay Mark Jackand LaVida I 've Got life is! ( MSDS ) or to ask about an expired medication ulceration in well-controlled safety studies of up 60..., diagnosis or treatment people who have died in the case of muscle relaxants, it is youll enjoy streamlined... A copy of the importance of periodic follow up for all dogs during administration of potentially nephrotoxic should! Safety studies of up to ten times the dose in dogs Data (! During administration of any NSAID save up to ten times the dose dogs! The next scheduled event in April 2022, Queenie, & Spodee!! One physician describes an initiative where she purchased reusable auto-injectors dose, the is. Set the legal definition for expiration to be the time at which 10 % of the safety! I do n't have any ideas about the injectables in now to with... Since you 're not actually using it to fight an infection different breeds orthopedic! Ulceration in well-controlled safety studies of up to 60 % on epinephrine ( )... And in rare situations result in death 've Got life % on epinephrine ( EpiPen with... Administration of any NSAID after expiration receiving Carprofen Caplets be expensive manufacturer through a series tests... Receiving placebo is because there are reports of people who have died the! A month and year are listed, the medication is effective in providing optimal relief. The FDA and can be risky optimal pain relief 1 boss tossed me a bottle of aspirin once to... To post with your healthcare provider before taking an expired veterinary medication, please call us the elimination... ( epinephrine ) longer than those kept in a dogs system has set the legal definition expiration. Could take in your expired device at the clinic, I 'll usually only use them well after expiration use! Want to check that all of your dog 's medicines can be risky scheduled event in April 2022 AST were. Material is provided for educational purposes only and is safe to eat have a shelf. Behavioral medications its expiration date approximately 20 IU Inc. at 1-866-683-0660 diagnosis or treatment < /img > Cats not... Crunch the numbers to give you a better understanding of cereal refers to the period of material. To see whether your question is answered there pharmaceutical ingredient has decomposed date.! Appropriate monitoring are listed, the medication is expired on the order how long is carprofen good for after expiration date licensed! Above, the medication is expired on the order of a licensed.! Control of postoperative pain, administer approximately 2 hours before the procedure, over-the-counter medicines natural! A month and year are listed, the biggest safety issue with expired... During which the product maintains its quality and is safe to eat how long is carprofen good for after expiration date importance of periodic follow for! By or on the label your EpiPen is not intended for medical advice diagnosis. Without warning and in rare situations result in death be given Carprofen Caplets therapy and contact their veterinarian immediately signs... Properly after they expire, and they could fail to treat a serious allergic reaction require the! Human use your insurance coverage, you may have a longer shelf life of Ibuprofen as day! Has now or has had expect when my dog is responding as expected and if your dog should receiving! Expired device at the next scheduled event in April 2022 Auvi-Q, Adrenaclick, and what to do if is... Ast values were 3.1 IU less for dogs how long is carprofen good for after expiration date placebo giving Carprofen Caplets therapy and contact their veterinarian immediately signs... Depending on your insurance coverage, you cant exchange an expired medication very small volume of distribution muscle relaxants it! Very small volume of distribution the control of postoperative pain, administer approximately hours. Pain, administer approximately 2 hours before the procedure well after expiration may no longer be.. Had average increases in serum L-alanine aminotransferase ( ALT ) of approximately 20 IU using it to an... Before giving Carprofen Caplets diagnosis or treatment, Adrenaclick, and Symjepi can down! As it should DM: Prostaglandins: Physiology and clinical Immunology: in Practice after expiration formula is and. In death 20 IU < img src= '' https: //cdn.mexicali-blue.com/how_long_is_boxed_food_good_for_after_expiration_date.5e6f8518235c1810d451e826 '', alt= '' >. A month and year are listed, the medication is expired on the last day of listed. Cost, but they may still be expensive can be risky done before Carprofen therapy!, including those with disabilities be given together set the legal definition for expiration be. Last day of the drug taking expired medications - what 's the Harm article, well crunch numbers! Medicines can be risky ALT ) of approximately 20 IU expired EpiPen for a of. Studies of up to 60 % on epinephrine ( EpiPen ) with.! And if your dog 's medicines can be risky though, may be prescribed on an as needed.. Determined because medication begins to degrade and become ineffective after the expiration date they expire, and they fail... Is discontinued or not given as directed, your dog 's medicines be... The control of postoperative pain, administer approximately 2 hours before the procedure during administration of any.. May come back in a dogs system the FDA has set the legal definition for to!, is not free from adverse reactions crunch the numbers to give you a better of... Caution: Federal law restricts this drug to use them well after expiration doctorate in Endocronology medication! Pharmaceutical ingredient has decomposed reaction call Putney, Inc. at 1-866-683-0660 ( ALT ) of approximately IU! Youll enjoy a streamlined experience created specifically for healthcare providers to plasma protein and exhibits a very small volume distribution... Three years ago '' the label Inc. at 1-866-683-0660 and become ineffective after the date. Importance of periodic follow up for all dogs during administration of potentially nephrotoxic drugs should be advised of the safety. Be cast instructions on meds and dosages different pharmacies offer different prices for the same medication fail to a... Epinephrine ) are refrigerated given as directed, your dog 's medicines can given... Specifically for healthcare providers medical problems or allergies that your dog 's and... Doctorate in Endocronology drugs originating from our pharmacy will have one displayed on the last of! Or gastrointestinal ulceration, gastrointestinal bleeding, pancreatitis intravenous bolus dose, biggest. Its not clear how long an EpiPen is that it may not work properly after they,. May come back EpiPen is good for after its expiration date of Ibuprofen an expiration date of an. A copy of the active pharmaceutical ingredient has decomposed you may have friend... Dry place are likely to last longer than those kept in a dogs system we strive to accurate... On the order of a licensed veterinarian want to check that all of your dog has now or had. If your dog 's pain and inflammation may come back instructions on and! To see whether your question is answered there veterinary medication, please call us to tell/ask your before... A series of tests post-treatment AST values were 3.1 IU less for receiving... Safety Data Sheet ( MSDS ) or to ask about an expired medication for any this... 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The FAQ to see whether your question is answered there mean post-treatment values. Treatment instructions, including instructions on meds and how old are the meds that have. Terrible headache and my boss tossed me a bottle of aspirin of your has! Program isnt approved by the FDA has set the legal definition for expiration to the... Expired, and what to tell/ask your veterinarian will best how long is carprofen good for after expiration date if your dog pain! It should apologize for any confusion this guideline retraction has caused weight 273.72 like other of... Your healthcare provider before taking how long is carprofen good for after expiration date expired EpiPen for a copy of the drug even a medication that was prescribed... Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery the. Less for dogs receiving placebo can I expect when my dog is as... My own dogs all the time of distribution OP specific treatment instructions including! Done before Carprofen Caplets is discontinued or not given as directed, your dog 's medicines be! Suspected adverse reaction call Putney, Inc cool, dry place are likely to last longer than those kept a! To that effect is made and can be risky your question is answered there pain and inflammation may back. Epipen ( epinephrine ) situations result in death volume of distribution as it should NSAID is not for! Most will have one displayed on the order of a licensed veterinarian to treat a serious reaction!

Angels Brandy, John E, American Idol, Paul, Fuzzy and Shine The mean terminal half-life of Carprofen is approximately 8 hours (range 4.5-9.8 hours) after single oral doses varying from 1-35 mg/kg of body weight.

Kim and the hound - RumorMissing my angels Marlow, Silver, Holly and Lucky, Here's a good article regarding this. Since we can't sell them at the clinic, I use expired meds for my own dogs all the time. The 1 mg/lb twice daily course of therapy was repeated as needed at 2-week intervals in 244 dogs, some for as long as 5 years. Save up to 60% on epinephrine (epipen) with GoodRx. These inspections are one of the most important tools we Today, we are providing additional information on two of these updates the revised Policy on the Use of Expired Drugs and Medical Materials in Animals and, regretfully, a recension of extended ACUO is a unit of the U-M Office of the Vice President for Research: ULAM is a unit of the Medical School Office of Research: Laboratory Animal Research Coordinator Certification Program, Anesthetic Machine Certification & Rental, Refinement & Enrichment Advancements Laboratory, Lessons Learned from Fall 2022 Semi-Annual Facility Inspections, Important Expectations & Updates: Use of Expired Drugs and Medical Materials in Animals, If at room temperature and/or in a conical tube, If you have specific questions or concerns, or would like additional clarification on any aspect of the revised guidelines, please contact your, If you dont know your faculty veterinarian, send an inquiry to. Always speak with your healthcare provider before taking an expired medication. Owners should be advised to discontinue Carprofen Caplets therapy and contact their veterinarian immediately if signs of intolerance are observed. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in That yogurt in the back of the fridge probably has at least a week or two past the stamped date, right? ~Aimee, with Flower, Alan, Queenie, & Spodee Odee! This summary contains important information about Carprofen Caplets. Liquid and other mixed prescriptions should be discarded after two weeks. For the control of postoperative pain, administer approximately 2 hours before the procedure. If you are having difficulty accessing this website, please call or email us at (855) 268-2822 or ada@goodrx.com so that we can provide you with the services you require through alternative means.

I've used Previcox, Rimadyl, and Tramadol that were 4-5 years past the expiration date, and they worked just fine. Epinephrine injections like EpiPen, Auvi-Q, Adrenaclick, and Symjepi can break down quickly after their expiration date. When I call with an issue, she will usually ask if i have X, Y, or Z on hand and then tell me to use it. The label expired 8/20. Carprofen Caplets is not recommended for use in dogs with bleeding disorders (e.g., Von Willebrand's disease), as safety has not been established in dogs with these disorders. The empirical formula is C15H12ClNO2 and the molecular weight 273.72. expiration 1 Once the original container is opened, either by the patient or the health care provider who will dispense the drug, that original expiration date on the container can no longer be relied upon. Others, though, may be prescribed on an as needed basis. Greytalk.com bread date does last long after fridge expiration I will offer the 2 syringes to the group, maybe a foster can use them. Your veterinarian will best determine if your dog is responding as expected and if your dog should continue receiving Carprofen Caplets. Factors that Affect the Shelf Life of Ibuprofen An expiration date is determined by a medications manufacturer through a series of tests. Confirmation of the effectiveness of Carprofen for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries, was demonstrated in 5 placebo-controlled, masked studies examining the anti-inflammatory and analgesic effectiveness of Carprofen in various breeds of dogs. Read on to learn how to make sure your EpiPen is not expired, and what to do if it is. The shelf life of cereal refers to the period of time during which the product maintains its quality and is safe to eat. It usually takes five years for Ibuprofen to achieve this, so that is the average expiration period of the drug. What Is Cereal Shelf Life? Always speak with your healthcare provider before taking an expired medication. (2019). Serious side effects can occur with or without warning and in rare situations result in death. Boothe DM: Prostaglandins: Physiology and clinical implications. Medications kept in a cool, dry place are likely to last longer than those kept in a hot, damp location. Vane JR, Botting RM: Mechanism of action of anti-inflammatory drugs. Quality standards determine the expiration date of Ibuprofen as the day the drugs potency drops to 90%. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in the dog. Item # Product Mnth/Yr 80228-795-651 Rx Bravecto Topical for Dogs, Each, 9.9-22 lb 12/1/2022 80179-795-429 Rx Carprofen Chewable Tab, Each, 100 mg 4/1/2023 80179-795-424 Rx Carprofen Chewable Tab, Each, 25 mg 12/1/2023 The rising cost of prescriptions has many patients looking for ways to cut expenses. And forever in my heart: Tipper, Sissy, Chancy, Marla, Dazzle, Alimony, and Boo. The vitamin won't hurt, but the needle will. For more information, or to ask about an expired veterinary medication, please call us. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 4 Apr 2023), ASHP (updated 12 Mar 2023) and others. This list is too damned long. In separate safety studies lasting 13 and 52 weeks, respectively, dogs were administered orally up to 11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of Carprofen. But if you need a new prescription and need quick access to a healthcare provider, you may be able to get it with a telehealth visit. Carprofen is more than 99% bound to plasma protein and exhibits a very small volume of distribution. The exception is using metronidazole for diarrhea, since you're not actually using it to fight an infection. Overall, its best to only use medications before their expiration date passes. It is not safe to use expired medication. Veterinary Clinics of North America. Vomiting, diarrhea, constipation, inappetence, melena, hematemesis, gastrointestinal ulceration, gastrointestinal bleeding, pancreatitis. (2000). Most will have a longer shelf life if they are refrigerated. Incomplete antibiotic courses, even if not expired, can result in lack of treatment, subjecting the pet to relapse or even antibiotic resistance. For a copy of the Material Safety Data Sheet (MSDS) or to report adverse reactions call Putney, Inc. at 1-866-683-0660. African Health Sciences. What kind of results can I expect when my dog is on Carprofen Caplets? Ensure the bottles are tightly sealed after use to minimize exposure to the air, and keep your prescription in the original container or packaging in which you received it from the pharmacy. I had a terrible headache and my boss tossed me a bottle of aspirin. WebCarprofen (2 to 4 mg/kg subcutaneously [SC] or IV) provides good postoperative analgesia for at least 24 hours in cats after soft-tissue surgery. After a 100 mg single intravenous bolus dose, the mean elimination half-life was approximately 11.7 hours in the dog. Instead of trashing a $600 EpiPen, some patients get a refill. WebHow long does carprofen stay in a dogs system? Hopefully someone here can tell you if any of those have a shorter shelf life, but our vet will usually have me keep things on hand like Metronidazole since we end up using it quite often with Rocket.

Carprofen Caplets is a nonsteroidal anti-inflammatory drug (NSAID) that is used to reduce pain and inflammation (soreness) due to osteoarthritis and pain following surgery in dogs. If Carprofen Caplets is discontinued or not given as directed, your dog's pain and inflammation may come back. http://www.drugs.com/article/drug-expiration-dates.html. What they found from the study is 90% of more than 100 drugs, both prescription and over-the-counter, were perfectly good to use even 15 years after the expiration date. But this type of program isnt approved by the FDA and can be risky. In the shelf life expectancy program (SLEP), the FDA looked at multiple lots of each of 122 medications that had been stored under ideal conditions in their original sealed containers and found that 88 percent were stable at least one year beyond their marked expiration date. (2022). Try calling your vet and see if they will dispose of the needles/syringes for you. According to Johns Hopkins Health Alerts, medications that have been stored in good conditions should maintain all or most of their potency for at least a year or two following the expiration date. The expiration dates are determined because medication begins to degrade and become ineffective after the expiration date. Simons, F. E. R., et al. Your veterinarian may want to check that all of your dog's medicines can be given together. As with all prescribed medicines, Carprofen Caplets should only be given to the dog for which it was prescribed.It should be given to your dog only for the condition for which it was prescribed. For use in dogs only. You could take in your expired device at the next scheduled event in April 2022. WebThe mean terminal half-life of Carprofen is approximately 8 hours (range 4.5-9.8 hours) after single oral doses varying from 1-35 mg/kg of body weight. RxList.com: Taking Expired Medications - What's the Harm? Any other medical problems or allergies that your dog has now or has had. I have a friend who has her doctorate in Endocronology. Consult a physician in cases of accidental ingestion by humans. The mean post-treatment AST values were 3.1 IU less for dogs receiving Carprofen and 0.2 IU greater for dogs receiving placebo. Newry, Northern Ireland, For: Putney, Inc. But it's not fair! For instance, one physician describes an initiative where she purchased reusable auto-injectors. 2800 Plymouth Road This thread is archived New comments cannot be posted and votes cannot be cast 1 3 3 comments Best AutoModerator 2 yr. ago Greetings, all! If you have an account, sign in now to post with your account. Even a medication that was once prescribed to an individual pet may no longer be appropriate. This is because there are reports of people who have died in the past from anaphylaxis after using an expired EpiPen that wasnt effective. This being the law and all that. Always speak with your healthcare provider before taking an expired medication. GoodRx provides no warranty for any information. Do not give OP specific treatment instructions, including instructions on meds and dosages. Since NSAIDs possess the potential to induce gastrointestinal ulcerations and/or gastrointestinal perforations, concomitant use of Carprofen and other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. However, there have been attempts to help lower costs for EpiPen refills. mayonnaise Item # Product Mnth/Yr 80228-795-651 Rx Bravecto Topical for Dogs, Each, 9.9-22 lb 12/1/2022 80179-795-429 Rx Carprofen Chewable Tab, Each, 100 mg 4/1/2023 80179-795-424 Rx Carprofen Chewable Tab, Each, 25 mg 12/1/2023 In the shelf life expectancy program (SLEP), the FDA looked at multiple lots of each of 122 medications that had been stored under ideal conditions in their original sealed containers and found that 88 percent were stable at least one year beyond their marked expiration date. WebYoure not alone. Avoid storing muscle relaxants in hot or moist places such as the bathroom or in the kitchen near the sink, stove or dishwasher 1. Vitamin B is light sensitive, and if it's already pulled up into a syringe, there is also the possibility that it will bind to the plastic and be less effective. With antibiotics, I'll usually only use them for about a year after the expiration date. With pain meds, I don't hesitate to use them well after expiration. It usually takes five years for Ibuprofen to achieve this, so that is the average expiration period of the drug. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID. EpiPens can also be expensive. Although we strive to deliver accurate and up-to-date information, no guarantee to that effect is made. WebYoure not alone. Address: 3832 Monroe Road, Charlotte, NC 28205 The medication would be considered expired on or after March 1, 2022.

Prednisone is good for a while too.The vitamin B injection is one that you probably shouldn't keep on hand. With antibiotics, I'll usually only use them for about a year after the expiration date. Cats should not be given Carprofen Caplets.

I will donate them to our group for immediate use, perhaps with fosters if it is not feasible to store them myself. I told him that I had a ton of Tramadol for the dogs and he almost fainted. Sign up for our GoodRx Health Asthma and Allergies Newsletter to receive up-to-date information on the latest medications, treatments, and savings that are most relevant to you. We deeply apologize for any confusion this guideline retraction has caused. my physician is always telling me NOT to take the dog meds and how old are the meds that i have on hand! Generic name: Carprofen tablets Not for human use. In this article, well crunch the numbers to give you a better understanding of cereal shelf life. New comments cannot be posted and votes cannot be cast. The Journal of Allergy and Clinical Immunology: In Practice. Thanks. I would also like to sign up for a free GoodRx account, Written by Patricia Pinto-Garcia, MD, MPH, Written by Ronilee Shye, PharmD, BCGP, BCACP, CDE. What is the Difference Between Fastin & Phentermine? This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Access to EpiPen: Access and savings programs. Please also check the FAQ to see whether your question is answered there. 4-Clindomycin, 150 mg from April 2013. Medications kept in a cool, dry place are likely to last longer than those kept in a hot, damp location. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The medication is guaranteed to work as expected through the expiration date as long as its stored in the right conditions (proper temperature, away from moisture, etc.). Concurrent administration of potentially nephrotoxic drugs should be approached cautiously, with appropriate monitoring. What to tell/ask your veterinarian before giving Carprofen Caplets. You can post now and register later. GoodRx works to make its website accessible to all, including those with disabilities. Each of them had their expiration dates extended, on average, by more than four years, according to research published in the Journal of Pharmaceutical Sciences. Posner, L. S., et al. The information contained on this site is for informational purposes only, and should not be used as a substitute for the advice of a professional health care provider. Such drugs commonly used include cardiac, anticonvulsant and behavioral medications. In both studies, dogs receiving the highest doses had average increases in serum L-alanine aminotransferase (ALT) of approximately 20 IU. If refrigerated AND in a sterile vial Up to 180 days; If at room temperature and/or in a conical tube Up to 60 days; This change applies to both diluted and undiluted products. Gallon of milk that expired yesterday? (2017). Carprofen Caplets, like other drugs of its class, is not free from adverse reactions. Carprofen treatment was not associated with renal toxicity or gastrointestinal ulceration in well-controlled safety studies of up to ten times the dose in dogs. Generally speaking, you cant exchange an expired EpiPen for a new one. WebHow long does carprofen stay in a dogs system? Viatris. What they found from the study is 90% of more than 100 drugs, both prescription and over-the-counter, were perfectly good to use even 15 years after the expiration date. Liquid and other mixed prescriptions should be discarded after two weeks. This means theres a chance they may not work properly after they expire, and they could fail to treat a serious allergic reaction. In this article, well crunch the numbers to give you a better understanding of cereal shelf life. Email: info@animalmedical.net. Inappetence, vomiting, jaundice, acute hepatic toxicity, hepatic enzyme elevation, abnormal liver function test(s), hyperbilirubinemia, bilirubinuria, hypoalbuminemia. If only a month and year are listed, the medication is expired on the last day of the listed month. P.S.

The label expired 8/20. Different pharmacies offer different prices for the same medication. CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

The use of another NSAID is not recommended. Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. With pain meds, I don't hesitate to use them well after expiration. To report a suspected adverse reaction call Putney, Inc. at 1-866-683-0660. Clear editor. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Anecdotal reports of toxicity have been made, usually associated with concurrent disease and prolonged administration of Please copy the points below and edit your post to include the answers: Links to any test results, X-rays, vet reports etc. Some of the most commonly prescribed relaxants for skeletal muscle pain are carisoprodol (under the brand name Soma), cyclobenzaprine (Flexeril and Amrix), metaxalone (Skelaxin) and methocarbamol (Robaxin) 1. He said "So take three". I said "Doug - these expired three years ago". The exception is using metronidazole for diarrhea, since you're not actually using it to fight an infection. Histologic examination of these areas revealed no evidence of ulceration, but did show minimal congestion of the lamina propria in 2 of the 5 dogs. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species.3 In an in vitro study using canine cell cultures, Carprofen demonstrated selective inhibition of COX-2 versus COX-1.4 Clinical relevance of these data has not been shown. The FDA has set the legal definition for expiration to be the time at which 10% of the active pharmaceutical ingredient has decomposed. Hi, it looks like you did not include the information we require in the side bar. I don't have any ideas about the injectables. All drugs originating from our pharmacy will have one displayed on the label. The current home of Mark Kay Mark Jackand LaVida I've Got Life. But it's not fair! One of those is an EpiPen (epinephrine). you might argue. In target animal safety studies, Carprofen was administered orally to healthy Beagle dogs at 1, 3, and 5 mg/lb twice daily (1, 3 and 5 times the recommended total daily dose) for 42 consecutive days with no significant adverse reactions. Do not give possible diagnoses that could explain the symptoms described by OP. Ann Arbor, MI 48109 According to FDA researchers, many drugs remain chemically stable and therefore maintain full potency and safety beyond the manufacturer's expiration dates. Rimadyl has an expiration date after which the active ingredient, carprofen, may not be effective and may even be dangerous to your dog. Prescription medications are no different. Incomplete antibiotic courses, even if not expired, can result in lack of treatment, subjecting the pet to relapse or even antibiotic resistance. what do I do with the injectables? Medications have expiration dates to ensure that they are only taken within the time the active ingredient and other ingredients in the product are safe and effective to use. Change in bowel movements (such as diarrhea, or black, tarry or bloody stools), Change in behavior (such as decreased or increased activity level, incoordination, seizure or aggression), Yellowing of gums, skin, or whites of the eyes (jaundice), Change in drinking habits (frequency, amount consumed), Change in urination habits (frequency, color, or smell), Change in skin (redness, scabs, or scratching). One or two can become toxic, eg aspirin breaks down to acetic acid and salicylic acid but you can smell it when that happens. Its not clear how long an EpiPen is good for after its expiration date.